Cowden Syndrome, the PTEN Hamartoma Tumour syndromes and the PTEN gene

Cowden syndrome, PTEN Hamartoma Tumour syndromes and the PTEN gene

When there is a mutation (change in the DNA code) in the PTEN gene, the signs and symptoms that occur can vary greatly, even from individual to individual in the same family. The syndromes include the following:

  • Cowden syndrome (discussed below)
  • Bannayan-Riley-Ruvalcaba syndrome (associated with a large head (macrocephaly), hamartomatous polyps in the intestine, lipomas and freckles on the penis)
  • Proteus and Proteus-like syndromes ("overgrowth" syndromes, usually diagnosed in childhood).

Cowden syndrome is a heritable cancer syndrome that affects 1:200,000 people.

Characteristic skin lesions develop over time and are present in almost all people with Cowden syndrome by the late 20’s. These lesions include trichilemmomas, papillomatous papules, acral keratosis and lipomas. You can see some examples here. They are not cancerous and usually require no treatment.

Macrocephaly (head circumference 97th percentile) is common and, in some individuals, intellectual delay.

Benign growths, such as hamartomas, are very common. These growths occur in the breast (benign fibrocystic breast disease in 80%), the thyroid (mulitnodular goitre in 60%), uterus (fibroids in 40%) and bowel (hamartomatous polyps in 30%).

The risk of cancer is increased:

  • the risk of breast cancer is 25% over a lifetime
  • the risk of uterine cancer is 5 to 10% over a lifetime
  • the risk of thyroid cancer is 5 to 10% over a lifetime.
  • the risk of kidney cancer is also 5 to 10% over a lifetime.

To reduce cancer risk, breast cancer screening should start at age 30, a hysterectomy should be considered at age 40 (after the woman has completed her family), an ultrasound of the kidneys should be considered every 2 years from age 40 and bowel cancer screening with colonoscopies should be considered every 5 years from age 35 or 40. To check the thyroid, a clinical examination of the neck by the GP is recommended every year from age 5. Ultrasounds of the neck are not required unless there are thyroid nodules present.

There is a 50% chance of a person who carries a germline ATM mutation, whether male or female, passing the mutation to their son or daughter. If a mutation is identified, then predictive testing is available for blood relatives.

Does this sound like you or your family? Has a PTEN mutation been detected in a blood relative? Make an appointment with Dr Hilda High at Sydney Cancer Genetics. It is a confidential opportunity to discuss your personal and family history of cancer and genetic testing can be organised, if needed.

These links may be useful

  • PTEN World and PTEN Foundation are support groups for individuals and families affected by PTEN related syndromes. They are based in the USA but have members worldwide.
  • The Cancer Genetics section of the Cancer Institute's eviQ website provides up-to-date Australian-based management guidelines
  • The US National Library of Medicine website has more information about this syndrome.